mRNA vaccine Sci-Tech Platform
Circular RNA technology, known as mRNA technology Version 2.0, offers superior advantages in production, delivery, and treatment.
Breakthrough 1: Circular RNA Bottom Layer Patent Platform (Clean-PIE)
①· Circular RNA: Second-generation mRNA technology, mRNA 2.0 version.
② · Co-introduces circular structures, protecting itself from nuclease degradation, making it more stable.
③ · Completely free from linear mRNA restrictions (no capping, no polyA, no modification).
④· Protein expression is long-lasting with ultra-long-chain mRNA, leading to stronger T-cell immune responses.
⑤· Clean-PIE circularization technology has independent intellectual property rights, high success rate, and does not introdu ce exogenous sequences
Breakthrough 2: Screening Novel Cationic Lipids with Independent Intellectual Property Rights; In-house Production of Core Cationic Lipids, Effectively Reducing Costs
Breakthrough 3: Shenlian Biomedical Circular RNA Vaccine GMP Production Workshop Construction
①·The Circular RNA vaccine GMP production workshop is currently under construction.
② ·The total building area is 3614 m², with a cleanroom area of 2222 m².
③· It is projected to complete construction and undergo GMP static inspection in early 2025.
④· Scaling up the industrial production of mRNA vaccine products, from pilot scale to commercial production.
⑤· Establishment and operation of a GMP system for vaccine production, enabling large-scale mass production capacity for Circular RNA vaccines and therapeutic products.
Breakthrough 4:Rabies Virus mRNA Vaccine Demonstrates Significantly Superior Immunogenic Efficacy Compared to Commercial Inactivated Vaccines